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Some doctors prescribe mirtazapine or other antidepressants to treat sleep disorders such as insomnia.An August 2012 report in the Annals of Clinical Psychiatry noted that mirtazapine had proven sleep-promoting effects, and that use of the drug should "be balanced with mirtazapine's ability to cause sedation-related side effects."Talk with your doctor about use of mirtazapine or other drugs to address sleep disorders.This includes possible suicidal thoughts, new or worsening anxiety, or panic attacks.

Mirtazapine usually works in your system for 20 to 40 hours.If you continue to smoke, your doctor may want to adjust your dose of mirtazapine. Be careful if you do anything that requires you to be alert. The recommended starting dose for mirtazapine is 15 milligrams (mg) per day.It should be taken in the evening, preferably before you go to sleep.Tell your doctor if you are using: This is only a partial list. Tell your doctor about all of the medications you use, including any over-the-counter drugs, vitamins, and herbal products.If you drink alcohol while taking mirtazapine, the combination could have an enhanced sedating effect. You should not drink alcohol or drive after taking mirtazapine.

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There have been no significant studies of mirtazapine use by pregnant women, and it's not known if mirtazapine can be passed through a mother's breast milk to a breastfeeding baby.

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